CELLUREON EV+
Concentrated MSC-Derived Secretome
Description:
Cellureon EV+ is a cell-free biologic formulation composed of the complete secretome of human Wharton’s Jelly–derived mesenchymal stem cells (WJ-MSCs). This includes soluble proteins, cytokines, chemokines, growth factors, and extracellular vesicles (EVs), providing broad-spectrum therapeutic potential for regenerative, immunomodulatory, and anti-inflammatory applications.
Mechanism of Action:
- Paracrine signaling: Modulates nearby cell behavior without the presence of living cells
- Immune modulation: Inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-1β)
- Tissue repair: Stimulates fibroblasts, angiogenesis, ECM remodeling
- Oxidative protection: Reduces ROS and cellular apoptosis under stress conditions
Technical Specifications:
Parameter: Value / Methodology
Cell Source: Human Wharton’s Jelly MSCs (GMP-grade)
Filtration: Tangential Flow Filtration (TFF) with 100 kDa MWCO
Content: EVs, soluble proteins, miRNAs, cytokines
Cell-free: No viable cells / DNA-free
Endotoxin tested: < 0.5 EU/mL
Sterility: Validated by microbiological testing
Particle Range: Mixed (50–300 nm EVs)
Protein Quantification: TPRS per batch
Storage:-20°C ( short term storage) −80 °C ( long term storage)
Applications:
- Intra-articular regenerative injections
- Topical dermatological treatments
- Inhalation therapies (preclinical)
- Post-surgical recovery or chronic inflammation